RapamycinFungusV1, Main, Exploration, bibRecord, 000478

TORC1 signaling regulates DNA replication via DNA replication protein levels.

Identifieur interne : 000478 ( Main/Exploration ); précédent : 000477; suivant : 000479

TORC1 signaling regulates DNA replication via DNA replication protein levels.

Auteurs : Kaori Yamamoto [Japon] ; Nishiho Makino [Japon] ; Masayoshi Nagai [Japon] ; Yoshimi Honma [Japon] ; Hiroyuki Araki [Japon] ; Takashi Ushimaru [Japon]

Source :

Biochemical and biophysical research communications [ 1090-2104 ] ; 2018.

RBID : pubmed:30316513

Descripteurs français

English descriptors

KwdEn :
- DNA Replication (MeSH), Minichromosome Maintenance Complex Component 3 (analysis), Minichromosome Maintenance Complex Component 3 (metabolism), Plasmids (MeSH), Saccharomyces cerevisiae (MeSH), Saccharomyces cerevisiae Proteins (analysis), Saccharomyces cerevisiae Proteins (metabolism), Signal Transduction (MeSH), Transcription Factors (metabolism).
MESH :
- chemical , analysis : Minichromosome Maintenance Complex Component 3, Saccharomyces cerevisiae Proteins.
- chemical , metabolism : Minichromosome Maintenance Complex Component 3, Saccharomyces cerevisiae Proteins, Transcription Factors.
- DNA Replication, Plasmids, Saccharomyces cerevisiae, Signal Transduction.

Abstract

Accurate DNA replication is at the heart of faithful genome transmission in dividing cells. DNA replication is strictly controlled by various factors. However, how environmental stresses such as nutrient starvation impact on these factors and DNA replication is largely unknown. Here we show that DNA replication is regulated by target of rapamycin complex 1 (TORC1) protein kinase, which is a central regulator of cell growth and proliferation in response to nutrients. TORC1 inactivation reduced the levels of various proteins critical for DNA replication initiation, such as Mcm3, Orc3, Cdt1, and Sld2, and retarded DNA replication. TORC1 inactivation promoted proteasome-mediated Mcm3 degradation. Skp1-Cullin-F-box (SCF)-Grr1 and PEST motif mediated Mcm3 degradation. TORC1-downstream factors PP2A-Cdc55 protein phosphatase and protein kinase A regulated Mcm3 degradation. This study showed that TORC1 signaling modulates DNA replication to coordinate cell growth and genome replication in response to nutrient availability.

DOI: 10.1016/j.bbrc.2018.10.018
PubMed: 30316513

Affiliations:

Japon

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000436
to stream Main, to step Curation: 000436

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">TORC1 signaling regulates DNA replication via DNA replication protein levels.</title>
<author><name sortKey="Yamamoto, Kaori" sort="Yamamoto, Kaori" uniqKey="Yamamoto K" first="Kaori" last="Yamamoto">Kaori Yamamoto</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021</wicri:regionArea>
<wicri:noRegion>422-8021</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Makino, Nishiho" sort="Makino, Nishiho" uniqKey="Makino N" first="Nishiho" last="Makino">Nishiho Makino</name>
<affiliation wicri:level="1"><nlm:affiliation>Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529</wicri:regionArea>
<wicri:noRegion>422-8529</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nagai, Masayoshi" sort="Nagai, Masayoshi" uniqKey="Nagai M" first="Masayoshi" last="Nagai">Masayoshi Nagai</name>
<affiliation wicri:level="1"><nlm:affiliation>Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529</wicri:regionArea>
<wicri:noRegion>422-8529</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Honma, Yoshimi" sort="Honma, Yoshimi" uniqKey="Honma Y" first="Yoshimi" last="Honma">Yoshimi Honma</name>
<affiliation wicri:level="1"><nlm:affiliation>Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529</wicri:regionArea>
<wicri:noRegion>422-8529</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Araki, Hiroyuki" sort="Araki, Hiroyuki" uniqKey="Araki H" first="Hiroyuki" last="Araki">Hiroyuki Araki</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Microbial Genetics, National Institute of Genetics, Yata 1111, Mishima, Shizuoka, 411-8540, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Microbial Genetics, National Institute of Genetics, Yata 1111, Mishima, Shizuoka, 411-8540</wicri:regionArea>
<wicri:noRegion>411-8540</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ushimaru, Takashi" sort="Ushimaru, Takashi" uniqKey="Ushimaru T" first="Takashi" last="Ushimaru">Takashi Ushimaru</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan; Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529, Japan. Electronic address: ushimaru.takashi@shizuoka.ac.jp.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan; Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529</wicri:regionArea>
<wicri:noRegion>422-8529</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:30316513</idno>
<idno type="pmid">30316513</idno>
<idno type="doi">10.1016/j.bbrc.2018.10.018</idno>
<idno type="wicri:Area/Main/Corpus">000436</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000436</idno>
<idno type="wicri:Area/Main/Curation">000436</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000436</idno>
<idno type="wicri:Area/Main/Exploration">000436</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">TORC1 signaling regulates DNA replication via DNA replication protein levels.</title>
<author><name sortKey="Yamamoto, Kaori" sort="Yamamoto, Kaori" uniqKey="Yamamoto K" first="Kaori" last="Yamamoto">Kaori Yamamoto</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021</wicri:regionArea>
<wicri:noRegion>422-8021</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Makino, Nishiho" sort="Makino, Nishiho" uniqKey="Makino N" first="Nishiho" last="Makino">Nishiho Makino</name>
<affiliation wicri:level="1"><nlm:affiliation>Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529</wicri:regionArea>
<wicri:noRegion>422-8529</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nagai, Masayoshi" sort="Nagai, Masayoshi" uniqKey="Nagai M" first="Masayoshi" last="Nagai">Masayoshi Nagai</name>
<affiliation wicri:level="1"><nlm:affiliation>Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529</wicri:regionArea>
<wicri:noRegion>422-8529</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Honma, Yoshimi" sort="Honma, Yoshimi" uniqKey="Honma Y" first="Yoshimi" last="Honma">Yoshimi Honma</name>
<affiliation wicri:level="1"><nlm:affiliation>Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529</wicri:regionArea>
<wicri:noRegion>422-8529</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Araki, Hiroyuki" sort="Araki, Hiroyuki" uniqKey="Araki H" first="Hiroyuki" last="Araki">Hiroyuki Araki</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Microbial Genetics, National Institute of Genetics, Yata 1111, Mishima, Shizuoka, 411-8540, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Microbial Genetics, National Institute of Genetics, Yata 1111, Mishima, Shizuoka, 411-8540</wicri:regionArea>
<wicri:noRegion>411-8540</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ushimaru, Takashi" sort="Ushimaru, Takashi" uniqKey="Ushimaru T" first="Takashi" last="Ushimaru">Takashi Ushimaru</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan; Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529, Japan. Electronic address: ushimaru.takashi@shizuoka.ac.jp.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan; Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529</wicri:regionArea>
<wicri:noRegion>422-8529</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Biochemical and biophysical research communications</title>
<idno type="eISSN">1090-2104</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DNA Replication (MeSH)</term>
<term>Minichromosome Maintenance Complex Component 3 (analysis)</term>
<term>Minichromosome Maintenance Complex Component 3 (metabolism)</term>
<term>Plasmids (MeSH)</term>
<term>Saccharomyces cerevisiae (MeSH)</term>
<term>Saccharomyces cerevisiae Proteins (analysis)</term>
<term>Saccharomyces cerevisiae Proteins (metabolism)</term>
<term>Signal Transduction (MeSH)</term>
<term>Transcription Factors (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Composant-3 du complexe de maintenance des minichromosomes (analyse)</term>
<term>Composant-3 du complexe de maintenance des minichromosomes (métabolisme)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Plasmides (MeSH)</term>
<term>Protéines de Saccharomyces cerevisiae (analyse)</term>
<term>Protéines de Saccharomyces cerevisiae (métabolisme)</term>
<term>Réplication de l'ADN (MeSH)</term>
<term>Saccharomyces cerevisiae (MeSH)</term>
<term>Transduction du signal (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Minichromosome Maintenance Complex Component 3</term>
<term>Saccharomyces cerevisiae Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Minichromosome Maintenance Complex Component 3</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Composant-3 du complexe de maintenance des minichromosomes</term>
<term>Protéines de Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Composant-3 du complexe de maintenance des minichromosomes</term>
<term>Facteurs de transcription</term>
<term>Protéines de Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>DNA Replication</term>
<term>Plasmids</term>
<term>Saccharomyces cerevisiae</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Plasmides</term>
<term>Réplication de l'ADN</term>
<term>Saccharomyces cerevisiae</term>
<term>Transduction du signal</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Accurate DNA replication is at the heart of faithful genome transmission in dividing cells. DNA replication is strictly controlled by various factors. However, how environmental stresses such as nutrient starvation impact on these factors and DNA replication is largely unknown. Here we show that DNA replication is regulated by target of rapamycin complex 1 (TORC1) protein kinase, which is a central regulator of cell growth and proliferation in response to nutrients. TORC1 inactivation reduced the levels of various proteins critical for DNA replication initiation, such as Mcm3, Orc3, Cdt1, and Sld2, and retarded DNA replication. TORC1 inactivation promoted proteasome-mediated Mcm3 degradation. Skp1-Cullin-F-box (SCF)-Grr1 and PEST motif mediated Mcm3 degradation. TORC1-downstream factors PP2A-Cdc55 protein phosphatase and protein kinase A regulated Mcm3 degradation. This study showed that TORC1 signaling modulates DNA replication to coordinate cell growth and genome replication in response to nutrient availability.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30316513</PMID>
<DateCompleted><Year>2019</Year>
<Month>05</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>05</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1090-2104</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>505</Volume>
<Issue>4</Issue>
<PubDate><Year>2018</Year>
<Month>11</Month>
<Day>10</Day>
</PubDate>
</JournalIssue>
<Title>Biochemical and biophysical research communications</Title>
<ISOAbbreviation>Biochem Biophys Res Commun</ISOAbbreviation>
</Journal>
<ArticleTitle>TORC1 signaling regulates DNA replication via DNA replication protein levels.</ArticleTitle>
<Pagination><MedlinePgn>1128-1133</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0006-291X(18)32160-0</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbrc.2018.10.018</ELocationID>
<Abstract><AbstractText>Accurate DNA replication is at the heart of faithful genome transmission in dividing cells. DNA replication is strictly controlled by various factors. However, how environmental stresses such as nutrient starvation impact on these factors and DNA replication is largely unknown. Here we show that DNA replication is regulated by target of rapamycin complex 1 (TORC1) protein kinase, which is a central regulator of cell growth and proliferation in response to nutrients. TORC1 inactivation reduced the levels of various proteins critical for DNA replication initiation, such as Mcm3, Orc3, Cdt1, and Sld2, and retarded DNA replication. TORC1 inactivation promoted proteasome-mediated Mcm3 degradation. Skp1-Cullin-F-box (SCF)-Grr1 and PEST motif mediated Mcm3 degradation. TORC1-downstream factors PP2A-Cdc55 protein phosphatase and protein kinase A regulated Mcm3 degradation. This study showed that TORC1 signaling modulates DNA replication to coordinate cell growth and genome replication in response to nutrient availability.</AbstractText>
<CopyrightInformation>Copyright © 2018 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yamamoto</LastName>
<ForeName>Kaori</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Makino</LastName>
<ForeName>Nishiho</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nagai</LastName>
<ForeName>Masayoshi</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Honma</LastName>
<ForeName>Yoshimi</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Araki</LastName>
<ForeName>Hiroyuki</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Division of Microbial Genetics, National Institute of Genetics, Yata 1111, Mishima, Shizuoka, 411-8540, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ushimaru</LastName>
<ForeName>Takashi</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan; Biological Science, Graduate School of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8529, Japan. Electronic address: ushimaru.takashi@shizuoka.ac.jp.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>10</Month>
<Day>11</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Biochem Biophys Res Commun</MedlineTA>
<NlmUniqueID>0372516</NlmUniqueID>
<ISSNLinking>0006-291X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C561842">TORC1 protein complex, S cerevisiae</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.4.12</RegistryNumber>
<NameOfSubstance UI="C507761">MCM3 protein, S cerevisiae</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.4.12</RegistryNumber>
<NameOfSubstance UI="D064126">Minichromosome Maintenance Complex Component 3</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D004261" MajorTopicYN="Y">DNA Replication</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064126" MajorTopicYN="N">Minichromosome Maintenance Complex Component 3</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010957" MajorTopicYN="N">Plasmids</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="Y">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">DNA replication</Keyword>
<Keyword MajorTopicYN="Y">Mcm3</Keyword>
<Keyword MajorTopicYN="Y">Proteasome</Keyword>
<Keyword MajorTopicYN="Y">SCF</Keyword>
<Keyword MajorTopicYN="Y">TORC1</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>09</Month>
<Day>25</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>10</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>10</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>5</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>10</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">30316513</ArticleId>
<ArticleId IdType="pii">S0006-291X(18)32160-0</ArticleId>
<ArticleId IdType="doi">10.1016/j.bbrc.2018.10.018</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Japon</li>
</country>
</list>
<tree><country name="Japon"><noRegion><name sortKey="Yamamoto, Kaori" sort="Yamamoto, Kaori" uniqKey="Yamamoto K" first="Kaori" last="Yamamoto">Kaori Yamamoto</name>
</noRegion>
<name sortKey="Araki, Hiroyuki" sort="Araki, Hiroyuki" uniqKey="Araki H" first="Hiroyuki" last="Araki">Hiroyuki Araki</name>
<name sortKey="Honma, Yoshimi" sort="Honma, Yoshimi" uniqKey="Honma Y" first="Yoshimi" last="Honma">Yoshimi Honma</name>
<name sortKey="Makino, Nishiho" sort="Makino, Nishiho" uniqKey="Makino N" first="Nishiho" last="Makino">Nishiho Makino</name>
<name sortKey="Nagai, Masayoshi" sort="Nagai, Masayoshi" uniqKey="Nagai M" first="Masayoshi" last="Nagai">Masayoshi Nagai</name>
<name sortKey="Ushimaru, Takashi" sort="Ushimaru, Takashi" uniqKey="Ushimaru T" first="Takashi" last="Ushimaru">Takashi Ushimaru</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000478 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000478 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:30316513
   |texte=   TORC1 signaling regulates DNA replication via DNA replication protein levels.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:30316513" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a RapamycinFungusV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 21:55:41 2020. Site generation: Thu Nov 19 22:00:39 2020

	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

TORC1 signaling regulates DNA replication via DNA replication protein levels.

TORC1 signaling regulates DNA replication via DNA replication protein levels.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki